Lower energy flux and higher aerobic glycolysis: constant growth

Fermentating glucose in the presence of enough oxygen to support respiration, known as aerobic glycolysis (a.k.a. Warburg effect) is believed to maximize growth rate. The cells support a constant biomass-production rate with decreasing rates of respiration and ATP production but also decrease their stress resistance. As the respiration rate decreases, so do the levels of enzymes catalyzing rate-determining reactions of the tricarboxylic-acid cycle (providing NADH for respiration) and of mitochondrial folate-mediated NADPH production (required for oxidative defense).

The findings demonstrate that exponential growth can represent not a single metabolic/physiological state but a continuum of changing states and that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival. (Constant Growth Rate Can Be Supported by Decreasing Energy Flux and Increasing Aerobic Glycolysis. Slavov Nikolai, Budnik Bogdan A, Schwab David, Airoldi Edoardo M, van Oudenaarden Alexander, Cell reports. 2014 Apr 24. PMID: 24767987)


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